IN RECENT YEARS, MULTIFUNCTIONAL NANO-MATERIALS HAVE ATTRACTED ENORMOUS INTEREST WITHIN THE BIOMEDICAL RESEARCH COMMUNITY. RATIONAL COMBINATION OF DIVERSE BUILDING BLOCKS SUCH AS METALLIC OR SEMICONDUCTOR NANOMOTIFS, ORGANIC MOLECULES/POLYMERS, BIOMOLECULES GIVE RISE TO COMPOSITE NANOMATERIALS WHICH EXHIBIT A WIDE RANGE OF DIAGNOSTIC AND SPECIFIC CELL TARGETING, DRUG STORAGE AND CONTROLLED DRUG RELEASE. IRON OXIDE MAGNETIC NANOPARTICLES (FE3O4 MNPS) AS THE CATALYST SUPPORTS, HAVE BEEN ATTRACTED MORE ATTENTIONS AS THEY CAN BE EASILY RECOVERED FROM THE REACTION MIXTURE, SIMPLY BY USING AN EXTERNAL MAGNET. RECENTLY, FE3O4 MNPS MODIFIED BY DIFFERENT FUNCTIONALIZED GROUPS WHICH HAVE SHOWN EXCELLENT CATALYTIC ACTIVITIES IN VARIOUS ORGANIC TRANSFORMATIONS. QUINOLONES ARE SYNTHETIC BROAD-SPECTRUM ANTIBIOTICS WITH GOOD ORAL ABSORPTION AND EXCELLENT BIOAVAILABILITY. DUE TO THE CHEMICAL FUNCTIONS FOUND ON THEIR NUCLEUS (A CARBOXYLIC ACID, AND IN MOST CASES A BASIC PIPERAZINYL), QUINOLONES BIND METAL IONS FORMING COMPLEXES IN WHICH THEY CAN ACT AS BIDENTATE, AS UNIDENTATE AND AS BRIDGING LIGAND, RESPECTIVELY. CIPROFLOXACIN (CPF) AS A QUINOLONES HAS LOW SOLUBILITY IN AQUEOUS SOLUTION AND HIGH RATE OF ABSORPTION FROM THE STOMACH. BY SUPPORTING CPFS ON MAGNETIC NANOPARTICLES SEPARATION AND INVESTIGATION ABOUT THE EFFECT OF THIS DRUG ARE SIMPLIFIED. FOR INSTANCE, THE CPF MNP CAN BE USED FOR STUDYING ABOUT COORDINATION OF CPF BY METALS AND ANTIBACTERIAL EFFECTS. HEREIN, MNPS HAVE BEEN SYNTHESIZED AND MODIFIED BY CPF LIGAND. THE SYNTHESIZED MAGNETIC NANOPARTICLES WERE CHARACTERIZED USING FT-IR, TEM AND XRD.

PHTHALOCYANINE IS AN INTENSELY BLUE-GREEN-COLOURED AROMATIC MACROCYCLIC COMPOUND THAT IS WIDELY USED IN DYEING. PHTHALOCYANINES FORM COORDINATION COMPLEXES WITH MOST ELEMENTS OF THE PERIODIC TABLE. THESE COMPLEXES ARE ALSO INTENSELY COLORED AND ALSO ARE USED AS DYES OR PIGMENTS. TODAY, THERE IS SUBSTITUTED PHTHALOCYANINE STUDIED BY CHEMISTS. PHTHALOCYANINE RING SUBSTITUENT POSITION DEPENDS ON STARTING MATERIALS [1]. ONE OF THE PHTHALOCYANINE'S PROPERTIES, MEDICINAL PROPERTIES OF THIS COMPOUNDS THAT KILLS CANCER TISSUES AND INFECTIONS. ANOTHER GOOD FEATURE OF THE SYNTHESIS THIS COMPOUND IS EXTENSIVE SYNTHESIS TECHNIQUES [2]. IN THIS STUDY, PHTHALIC ANHYDRIDE IN PRESENCE OF UREA AND CATALYTIC AMOUNT OF BORIC ACID REACTED IN NITRO-BENZENE AS SOLVENT.MAGNETIC NANOPARTICLE DRUG CARRIERS CONTINUE TO ATTRACT CONSIDERABLE INTEREST FOR DRUG TARGETING IN THE TREATMENT OF CANCERS AND OTHER PATHOLOGICAL CONDITIONS. THE EFFICIENT DELIVERY OF THERAPEUTIC LEVELS OF DRUG TO A TARGET SITE WHILE LIMITING NONSPECIFIC, SYSTEMIC TOXICITY REQUIRES OPTIMIZATION OF THE LOCALLY DRUG CONCENTRATION, IT DEPENDS TO THE APPLIED MAGNETIC FIELD, AND THE TREATMENT PROTOCOL [3]. WITH RESPECT TO DRUG TARGETING, USING NANOPARTICLE'S CARRIERS CONSIDERED. THIS ASPECT INVOLVES THE SYNTHESIS OF MODIFIED MAGNETIC NICKEL-PHOSPHORUS NANOPARTICLES; AND THEIR INSERTING TO THE RING HOLE OF PHTHALOCYANINE.

STAR-SHAPED POLYMERS ARE THE SIMPLEST CLASS OF BRANCHED POLYMERS WITH A GENERAL STRUCTURE CONSISTING OF SEVERAL (MORE THAN THREE) LINEAR CHAINS CONNECTED TO A CENTRAL CORE [1]. THE CORE, OR THE CENTER OF THE POLYMER CAN BE AN ATOM, MOLECULE, OR MACROMOLECULE; THE CHAINS, OR ―ARMS‖, CONSIST OF VARIABLE-LENGTH ORGANIC CHAINS. STAR-SHAPED POLYMERS IN WHICH THE ARMS ARE ALL EQUIVALENT IN LENGTH AND STRUCTURE ARE CONSIDERED HOMOGENEOUS, AND ONES WITH VARIABLE LENGTHS AND STRUCTURES ARE CONSIDERED HETEROGENEOUS.STAR-SHAPED POLYMERS' UNIQUE SHAPE AND ASSOCIATED PROPERTIES, SUCH AS THEIR COMPACT STRUCTURE, HIGH ARM DENSITY, EFFICIENT SYNTHETIC ROUTES, AND UNIQUE RHEOLOGICAL PROPERTIES MAKE THEM PROMISING TOOLS FOR USE IN DRUG DELIVERY [2], BIOMEDICAL APPLICATIONS [3].

STAR-SHAPED POLYMERS ARE THE SIMPLEST CLASS OF BRANCHED POLYMERS WITH A GENERAL STRUCTURE CONSISTING OF SEVERAL (MORE THAN THREE) LINEAR CHAINS CONNECTED TO A CENTRAL CORE. THE CORE, OR THE CENTER OF THE POLYMER CAN BE AN ATOM, MOLECULE, OR MACROMOLECULE; THE CHAINS, OR "ARMS", CONSIST OF VARIABLE-LENGTH ORGANIC CHAINS. STAR-SHAPED POLYMERS IN WHICH THE ARMS ARE ALL EQUIVALENT IN LENGTH AND STRUCTURE ARE CONSIDERED HOMOGENEOUS, AND ONES WITH VARIABLE LENGTHS AND STRUCTURES ARE CONSIDERED HETEROGENEOUS. STAR-SHAPED POLYMERS' UNIQUE SHAPE AND ASSOCIATED PROPERTIES, SUCH AS THEIR COMPACT STRUCTURE, HIGH ARM DENSITY, EFFICIENT SYNTHETIC ROUTES, AND UNIQUE RHEOLOGICAL PROPERTIES MAKE THEM PROMISING TOOLS FOR USE IN DRUG DELIVERY, BIOMEDICAL APPLICATIONS.